홈 > 연구소 > 논문 / 학술활동
연구소
마마파파&베이비의 핵심인 베이비 드림 난임 연구소는
그간의 연구학술 성과에 안주하지 않고,
늘 한계를 뛰어넘기 위해 노력합니다.
2016년 유럽불임학회(ESHRE) P-062 How long should we keep ejaculatory abstinence (EA) before intrauterine insemination (IUI)? (인공수정시술을 하기 전 얼마나 오래 금욕을 해야 하는가?)
J.W. Kim, K.H. Lee, I.H. Park, H.G. Sun, H.J. Chi, S.G. Kim, Y.Y. Kim, S.J. Kwak, J.Y. Park, C.S. Yoo
Mamapapa & Baby Obstetrics & Gynecology Clinic, Infertility, Ulsan, South Korea.
Is ejaculatory abstinence before IUI essential factor for pregnancy?
The period of ejaculatory abstinence before IUI is not related with pregnancy rates
The total number of motile sperm inseminated has been cited as the most predictive index of conception in IUI cycles. Intercourse on the day of hCG administration might cause concern about a lower recovery of total motile sperm. However, optimal period of ejaculatory abstinence before IUI is not yet established.
Retrospective analysis of 804 IUI cycles performed between April and December in 2015. The period of ejaculatory abstinence before IUI, semen analysis parameters of the ejaculate (pre-wash) and the insemination specimen (post-wash) for IUI, and pregnancy rate following ovulation induction and IUI were recorded.
The whole ejaculate was prepared for insemination using a technique of density gradient separation with centrifugation. Ejaculatory period before IUI was divided into 3groups (0-2 days, 3-5days, >5 days).
In each group, age, semen volume, sperm motility (pre-wash) and liquefaction time did not show significant differences. Although the longer EA period, the more total motile sperm count (pre-wash) was observed (88.2, 137.2, 194.7(*106/ml), p<0.05), but there were no significant differences in post-wash total motile sperm count (8.3, 10.9, 11.7 (*106/ml), p>0.05). Total pregnancy rate was 19.4% (144/804). There were no significant differences among three groups in the pregnancy rate (22.5% (14/80), 18.7% (53/310), 19.3% (77/414); p>0.05).
To identify the period of EA, we asked for questionnaire survey to patients. So, there could be recall bias. Prospective randomized studies with larger sample size will be required to confirm our conclusions.
There were few studies about relation between pregnancy rate and period of EA before IUI. Our result shows that period of EA before IUI does not affect pregnancy rate. Therefore, we can advise that abstinence before IUI and the interval of intercourse seldom affect pregnancy outcome.